Cell Trends, Inc. - Hollow Fiber Bioreactor Systems Cartridge Products and Services

Overview of the Hollow Fiber Bioreactor Systems
Our Hollow Fiber Bioreactor Systems are phenomenal. Whether you order a small, medium, or large system, you won't be disappointed in the yield of soluble and membrane-bound protein production.

Cell Trends assembles custom hollow fiber (HF) bioreactor systems using proprietary designs and artificial capillary cell culture methodology. Available in three cartridge sizes, our systems boost production of monoclonal antibodies, recombinant proteins, and adenoviral vectors, for example, to phenomenal levels. Cells are inoculated into the extracapillary space (ECS) of the cartridge and settle on the outer surface of a network of capillaries. Growth media circulating through the capillaries allow nutrients and oxygen to diffuse through the capillary walls to nourish the cells. Similarly, metabolic waste diffuses away from the cells and is diluted into the circulating media. Secreted products are preserved in the ECS, thereby maintaining a stable environment that approximates in vivo conditions.

Three Hollow Fiber Bioreactor Systems Cartridge Products Sizes Available

» Small

0.1Mm pore size for the highest exchange rate
Activated fiber for attachment of matrix proteins, cytokines, and antibodies
Ideal for endothelial cell and hepatocyte culture

» Medium

Low MWCO (5kd) fiber size can produce 100 µg/ml of recombinant protein in 15 ml of ECS harvest
High MWCO (20kd) fiber size can produce 50-100 mg of monoclonal antibody every 2 days
Both able to support up to 10⁹ cells

» Large

Low MWCO (5kd) fiber size can produce 100 µg/ml of recombinant protein in 70 ml of ECS harvest
High MWCO (20kd) fiber size can produce 75-150 mg of monoclonal antibody every 2 days
Both able to support up to 10⁹ cells

Ordering Information

Our HF Bioreactor technical team will work with you to select the cartridge size appropriate for your cell line and secreted product. A quotation will be provided for the initial set up of your system as well as for the weekly maintenance and an estimate of harvest volumes per week.